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refined pancreaticobiliary fish probe set (1q21 [mcl1], 7p12 [egfr], 8q24 [myc], and 9p21 [cdkn2a)]  (Abbott Laboratories)

 
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    Abbott Laboratories refined pancreaticobiliary fish probe set (1q21 [mcl1], 7p12 [egfr], 8q24 [myc], and 9p21 [cdkn2a)]
    Refined Pancreaticobiliary Fish Probe Set (1q21 [Mcl1], 7p12 [Egfr], 8q24 [Myc], And 9p21 [Cdkn2a)], supplied by Abbott Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/9p21+probe/mcl1+probe/pmc12262981-69-44-49
    Average 90 stars, based on 1 article reviews
    refined pancreaticobiliary fish probe set (1q21 [mcl1], 7p12 [egfr], 8q24 [myc], and 9p21 [cdkn2a)] - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Fluorescence:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Hybridization:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Fluorescence In Situ Hybridization:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Methylation:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Multiplex Assay:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Amplification:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Multiplex Ligation-dependent Probe Amplification:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Mutagenesis:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Immunohistochemistry:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    Next-Generation Sequencing:

    Article Title: Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
    Article Snippet: .. CDKN2A status was assessed by fluorescence in-situ hybridisation (FISH) using a 9p21 probe (Vysis LSI 9p21; Abbot Molecular Inc., Des Plaines, IL, USA), labelled with spectrum-red 2824 fluorophore, and a Chr9 centromeric probe (Vysis LSI CEP; Abbott) labelled with spectrum-green fluorophore and with Salsa methylation-specific multiplex ligationdependent probe amplification (MLPA) probemix ME024-B2 9p21 CDKN2A/2B region (MRC-Holland, Amsterdam, the Netherlands).15 We further obtained information on BRAF and NRAS mutation status by immunohistochemistry (anti-BRAF V600E, clone: VE1; Ventana ; anti-RAS Q61R, clone: SP174 Abcam , respectively) and/or next-generation sequencing (NGS) for atypical and malignant lesions. ..

    other:

    Article Title: Detection of copy number variations in melanocytic lesions utilising array based comparative genomic hybridisation.
    Article Snippet: Detection of copy number variations in melanocytic lesions utilising array based comparative genomic hybridisation NIMA MESBAH ARDAKANI, CARLA THOMAS, CLEO ROBINSON, KYM MINA, NATHAN TOBIAS HARVEY, BENHUR AMANUEL AND BENJAMIN ANDREW WOOD 1Department of Anatomical Pathology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, 2University of Western Australia, School of Pathology and Laboratory Medicine, Crawley, and 3Department of Diagnostic Genomics, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, WA, Australia



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    Image Search Results


    Correlation of MTAP expression by IHC and 9p21 copy number by NGS and CDKN2A FISH. (A) OncoPrint of histologic subtype, tumor purity (light red bars: ≤20%), MTAP expression (clones mAb 1813 and EPR6893), 9p21 copy number (CN) determined by integer copy number by FACETS, and detection of CDKN2A homozygous deletion by FISH; see for further details. (B) Contingency tables of MTAP loss using mAb 1813 and 9p21 homozygous deletion (Homdel) by FACETS and/or FISH in the entire study cohort (top), cases with tumor purity >20% (homozygous deletion by FACETS only) and cases with tumor purity ≤20% (homozygous deletion by FISH only) (bottom). FACETS, Fraction and Allele-Specific Copy Number Estimates from Tumor Sequencing; FISH, fluorescence in situ hybridization; mAb, monoclonal antibodies.

    Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    Article Title: Comparison of Immunohistochemistry, Next-generation Sequencing and Fluorescence In Situ Hybridization for Detection of MTAP Loss in Pleural Mesothelioma

    doi: 10.1016/j.modpat.2023.100420

    Figure Lengend Snippet: Correlation of MTAP expression by IHC and 9p21 copy number by NGS and CDKN2A FISH. (A) OncoPrint of histologic subtype, tumor purity (light red bars: ≤20%), MTAP expression (clones mAb 1813 and EPR6893), 9p21 copy number (CN) determined by integer copy number by FACETS, and detection of CDKN2A homozygous deletion by FISH; see for further details. (B) Contingency tables of MTAP loss using mAb 1813 and 9p21 homozygous deletion (Homdel) by FACETS and/or FISH in the entire study cohort (top), cases with tumor purity >20% (homozygous deletion by FACETS only) and cases with tumor purity ≤20% (homozygous deletion by FISH only) (bottom). FACETS, Fraction and Allele-Specific Copy Number Estimates from Tumor Sequencing; FISH, fluorescence in situ hybridization; mAb, monoclonal antibodies.

    Article Snippet: CDKN2A (9p21) FISH probe of 222 kb, labeled in orange, was used in combination with a centromere-specific probe for chromosome 9 (CEP9), labeled in green (both from Abbott Molecular).

    Techniques: Expressing, Clone Assay, Sequencing, Fluorescence, In Situ Hybridization, Bioprocessing

    MTAP loss in tumors lacking 9p21 deletion. MTAP staining was completely absent in tumor cells of a NET of the lung (A), a NET of the ileum (B), a colorectal NET (C), a pancreatic NET (D), a T-cell non-Hodgkin lymphoma (E), a marginal cell lymphoma (F) and in 2 cases of Hodgkin lymphoma (G and H). Distinct MTAP positivity of intermingled stroma cells serves as a positive internal control.

    Journal: The American Journal of Surgical Pathology

    Article Title: Prevalence of S-methyl-5′-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer

    doi: 10.1097/PAS.0000000000002297

    Figure Lengend Snippet: MTAP loss in tumors lacking 9p21 deletion. MTAP staining was completely absent in tumor cells of a NET of the lung (A), a NET of the ileum (B), a colorectal NET (C), a pancreatic NET (D), a T-cell non-Hodgkin lymphoma (E), a marginal cell lymphoma (F) and in 2 cases of Hodgkin lymphoma (G and H). Distinct MTAP positivity of intermingled stroma cells serves as a positive internal control.

    Article Snippet: A commercial 315 kilobases (kb) FISH probe spanning the 194 kb region on chromosome 9p21 where the CDKN2A (27 kb) and the MTAP (135 kb) gene localize was utilized for 9p21 copy number detection (ZytoLight SPEC CDKN2A/CEN 9 Dual Color Probe, Zytovision; #Z-2063).

    Techniques: Staining, Control

    MTAP loss in tumors with homozygous 9p21 deletion. MTAP staining was completely lacking in tumor cells of an (epithelioid) malignant mesothelioma (A), a urothelial carcinoma of the renal pelvis (B), a mucinous ovarian carcinoma (C), a serous high-grade ovarian carcinoma (D), a malignant melanoma (E), a recurrent adenocarcinoma of the prostate (F), a colorectal adenocarcinoma (G), and a ductal adenocarcinoma of the pancreas (H). Distinct MTAP positivity of intermingled stroma cells and of non-neoplastic epithelial cells serves as a positive internal control.

    Journal: The American Journal of Surgical Pathology

    Article Title: Prevalence of S-methyl-5′-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer

    doi: 10.1097/PAS.0000000000002297

    Figure Lengend Snippet: MTAP loss in tumors with homozygous 9p21 deletion. MTAP staining was completely lacking in tumor cells of an (epithelioid) malignant mesothelioma (A), a urothelial carcinoma of the renal pelvis (B), a mucinous ovarian carcinoma (C), a serous high-grade ovarian carcinoma (D), a malignant melanoma (E), a recurrent adenocarcinoma of the prostate (F), a colorectal adenocarcinoma (G), and a ductal adenocarcinoma of the pancreas (H). Distinct MTAP positivity of intermingled stroma cells and of non-neoplastic epithelial cells serves as a positive internal control.

    Article Snippet: A commercial 315 kilobases (kb) FISH probe spanning the 194 kb region on chromosome 9p21 where the CDKN2A (27 kb) and the MTAP (135 kb) gene localize was utilized for 9p21 copy number detection (ZytoLight SPEC CDKN2A/CEN 9 Dual Color Probe, Zytovision; #Z-2063).

    Techniques: Staining, Control

    Concordance rate of MTAP IHC and 9p21 copy number analysis.

    Journal: The American Journal of Surgical Pathology

    Article Title: Prevalence of S-methyl-5′-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer

    doi: 10.1097/PAS.0000000000002297

    Figure Lengend Snippet: Concordance rate of MTAP IHC and 9p21 copy number analysis.

    Article Snippet: A commercial 315 kilobases (kb) FISH probe spanning the 194 kb region on chromosome 9p21 where the CDKN2A (27 kb) and the MTAP (135 kb) gene localize was utilized for 9p21 copy number detection (ZytoLight SPEC CDKN2A/CEN 9 Dual Color Probe, Zytovision; #Z-2063).

    Techniques: